Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30996639 | 0.86 | ALDH1A1 (0.58) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL28504582 | 0.84 | ERN1 (0.58) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL13323847 | 0.81 | ERN1 (0.47) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL2203559 | 0.80 | ALDH1A1 (0.56) | ALDH1A1OR51E2CYP1A2MAPTLMNA | |
| SCHEMBL5597294 | 0.80 | GAA (0.53) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL31432473 | 0.79 | TRIM24 (0.56) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL2095308 | 0.79 | OR51E2 (0.48) | ERN1ALDH1A1OR51E2CYP1A2MAPT | |
| SCHEMBL30505740 | 0.78 | ERN1 (0.51) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL1161802 | 0.78 | ERN1 (0.56) | ERN1ALDH1A1TRIM24TYRTRIM33 | |
| SCHEMBL29951677 | 0.78 | ERN1 (0.56) | ERN1ALDH1A1TRIM24TYRTRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456197-B1 | PIPERIDINE-2,6-DIONES THAT ARE HETEROCYCLICALLY SUBSTITUTED IN POSITION 3 | GRUENENTHAL GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| US-7183274-B2 | Piperidine-2,6-diones heterocyclically substituted in the 3-position | GRUENENTHAL GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| US-20050020581-A1 | Piperidine-2,6-diones heterocyclically substituted in the 3-position | GRUENENTHAL GMBH (DE) | 2005-01-27 | — | — | US | disclosed |
| EP-1456197-A1 | PIPERIDINE-2,6-DIONES THAT ARE HETEROCYCLICALLY SUBSTITUTED IN POSITION 3 | Grünenthal GmbH (DE) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053956-A1 | PIPERIDINE-2,6-DIONES THAT ARE HETEROCYCLICALLY SUBSTITUTED IN POSITION 3 | Grünenthal GmbH (DE) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020581-A1 | Piperidine-2,6-diones heterocyclically substituted in the 3-position | DPYD, CYP2D6, DHPS | ERN1 3571/4885ALDH1A1 128/4885TRIM24 4774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.