Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.45 |
| ▸ | GCGR | P47871 | 6/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MATK | P42679 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222256 | 0.84 | PTGS1 (0.46) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL5225080 | 0.77 | NPSR1 (0.50) | PTGS1MAPK14MAPK11MEN1ALDH1A1 | |
| SCHEMBL5222107 | 0.75 | PTGS1 (0.39) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL5227509 | 0.75 | MAPT (0.55) | MEN1ALDH1A1KMT2ANPSR1PTGS2 | |
| SCHEMBL6725855 | 0.73 | PTGS1 (0.57) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL3939765 | 0.72 | MAPK14 (0.45) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL396399 | 0.72 | ALDH1A1 (0.46) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL7773094 | 0.72 | PTGS1 (0.49) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL6721530 | 0.71 | PTGS1 (0.59) | PTGS1MAPK14GCGRMAPK13MAPK12 | |
| SCHEMBL5223261 | 0.71 | GSK3B (0.42) | MEN1ALDH1A1KMT2ANPSR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |