Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221810 | 0.82 | ALDH1A1 (0.46) | NPSR1ALDH1A1LMNAATMSMN1; SMN2 | |
| SCHEMBL5227807 | 0.78 | ALDH1A1 (0.42) | NPSR1ALDH1A1LMNAATMSMN1; SMN2 | |
| SCHEMBL5223523 | 0.77 | PTGS1 (0.47) | NPSR1ALDH1A1MEN1KMT2ACSNK1D | |
| SCHEMBL5229288 | 0.77 | NPSR1 (0.42) | NPSR1ALDH1A1LMNAATMSMN1; SMN2 | |
| SCHEMBL19114473 | 0.74 | PTGS2 (0.52) | ALDH1A1LMNASMN1; SMN2L3MBTL1MEN1 | |
| Diphenylsulfane SCHEMBL8484020 | 0.72 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL17283468 | 0.72 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL9018824 | 0.72 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL5223261 | 0.72 | GSK3B (0.42) | NPSR1ALDH1A1LMNAATMSMN1; SMN2 | |
| SCHEMBL5224594 | 0.71 | ADORA2A (0.41) | NPSR1ALDH1A1LMNAATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | claimed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | claimed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | claimed |
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |