Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229288 | 0.89 | NPSR1 (0.42) | SMN1; SMN2ALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL5222256 | 0.88 | PTGS1 (0.46) | GSK3BALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL5224594 | 0.86 | ADORA2A (0.41) | GSK3BSMN1; SMN2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL5225534 | 0.76 | PTGS2 (0.58) | — | |
| SCHEMBL3943701 | 0.74 | HPGD (0.50) | GSK3BSMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL22815615 | 0.73 | RAB9A (0.52) | GSK3BSMN1; SMN2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL5224015 | 0.73 | SLC6A4 (0.35) | ALDH1A1NPSR1KMT2AMEN1MAPK1 | |
| SCHEMBL5222119 | 0.72 | KMT2A (0.44) | SMN1; SMN2ALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL1752937 | 0.72 | CSNK1D (0.47) | SMN1; SMN2ALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL5225080 | 0.72 | NPSR1 (0.50) | SMN1; SMN2ALDH1A1NPSR1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |