Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223229 | 0.96 | KDM4E (0.41) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5226784 | 0.85 | PIK3C3 (0.39) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5223226 | 0.84 | KDM4E (0.38) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5224667 | 0.82 | PIK3C3 (0.37) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5224665 | 0.82 | PIK3C3 (0.37) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5222772 | 0.82 | KDM4E (0.41) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5217755 | 0.82 | CTSD (0.37) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5221011 | 0.81 | CTSD (0.39) | SMN1; SMN2PIK3C3CTSDBACE1BACE2 | |
| SCHEMBL5221774 | 0.81 | BACE1 (0.49) | SMN1; SMN2PIK3C3CTSDBACE1BACE2 | |
| SCHEMBL5218540 | 0.81 | ALDH1A1 (0.43) | KDM4ENPC1SMN1; SMN2PIK3C3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |