Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 7/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222292 | 0.96 | POLB (0.59) | POLBKMOTP53PTGER1F10 | |
| SCHEMBL5224062 | 0.87 | KMO (0.43) | POLBKMOCREBBP | |
| SCHEMBL5216490 | 0.85 | TP53 (0.44) | POLBTP53F10AKR1C3MAPT | |
| SCHEMBL5222301 | 0.83 | POLB (0.43) | POLBKMOCREBBPBACE1BACE2 | |
| SCHEMBL5223381 | 0.82 | POLB (0.45) | POLBTP53BACE1BACE2MAPT | |
| SCHEMBL5900600 | 0.79 | POLB (0.59) | POLBTP53PTGER1F10MAPT | |
| SCHEMBL18767065 | 0.75 | POLB (0.54) | POLBTP53PTGER1BACE1BACE2 | |
| SCHEMBL30912307 | 0.74 | KMO (0.70) | POLBKMOCREBBP | |
| SCHEMBL27893460 | 0.74 | KMO (0.65) | POLBKMOCREBBP | |
| SCHEMBL5218382 | 0.74 | TP53 (0.43) | POLBTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |