Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224068 | 0.96 | POLB (0.53) | POLBKMOBACE1BACE2TP53 | |
| SCHEMBL5222301 | 0.87 | POLB (0.43) | POLBKMOBACE1BACE2CREBBP | |
| SCHEMBL5223381 | 0.85 | POLB (0.45) | POLBBACE1BACE2TP53 | |
| SCHEMBL5224062 | 0.83 | KMO (0.43) | POLBKMOCREBBP | |
| SCHEMBL5216490 | 0.81 | TP53 (0.44) | POLBTP53AKR1C3F10 | |
| SCHEMBL3886939 | 0.79 | POLB (0.64) | POLBCA1CA2CA6OPRK1 | |
| SCHEMBL13229564 | 0.75 | POLB (0.60) | POLBBACE1BACE2TP53PTGER1 | |
| SCHEMBL5900600 | 0.75 | POLB (0.59) | POLBTP53PTGER1F10 | |
| SCHEMBL5221112 | 0.75 | POLB (0.44) | POLBTP53 | |
| SCHEMBL5259083 | 0.74 | POLB (0.41) | POLBKMOBACE1BACE2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |