Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.31 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222301 | 0.96 | POLB (0.43) | KMOPOLBCREBBPACMSDKMT2A | |
| SCHEMBL5224068 | 0.87 | POLB (0.53) | KMOPOLBCREBBP | |
| SCHEMBL5216487 | 0.85 | ALDH1A1 (0.39) | KMOKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL5222292 | 0.83 | POLB (0.59) | KMOPOLBCREBBP | |
| SCHEMBL5223389 | 0.82 | ALDH1A1 (0.38) | KMOPOLBALDH1A1KDM4EHPGD | |
| SCHEMBL30912307 | 0.74 | KMO (0.70) | KMOPOLBCREBBPACMSDKMT2A | |
| SCHEMBL27893460 | 0.74 | KMO (0.65) | KMOPOLBCREBBPACMSDKMT2A | |
| SCHEMBL5218376 | 0.74 | GAA (0.38) | POLBKMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL5220758 | 0.74 | BACE1 (0.52) | CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5220753 | 0.74 | BACE1 (0.52) | CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |