SCHEMBL5224070

SCHEMBL5224070

CC(C)(C)N(C(=O)O)[C@@H](Cc1cccc(Cl)c1)[C@H](O)CNC1CCCCC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.47
BACE1 P56817 5/20 0.45
CTSD P07339 4/20 0.45
BACE2 Q9Y5Z0 4/20 0.45
MAPT P10636 2/20 0.44
CTSV O60911 2/20 0.43
CTSL P07711 2/20 0.43
CTSS P25774 2/20 0.43
CTSK P43235 1/20 0.43
ALDH1A1 P00352 1/20 0.43
GAA P10253 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
KDM4E B2RXH2 1/20 0.40
ALOX12 P18054 1/20 0.40
THRB P10828 1/20 0.39
HPGD P15428 1/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
LMNA P02545 2/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5224084 1.00 EPHX2 (0.47) EPHX2BACE1CTSDBACE2MAPT
SCHEMBL5218771 0.88 POLB (0.43) BACE1CTSDBACE2GAAKDM4E
SCHEMBL5218781 0.88 POLB (0.43) BACE1CTSDBACE2GAAKDM4E
SCHEMBL5930323 0.84 SLC6A2 (0.43) CTSVCTSLCTSSCTSKLMNA
SCHEMBL5930327 0.84 SLC6A2 (0.43) CTSVCTSLCTSSCTSKLMNA
SCHEMBL5220548 0.82 KDM4E (0.44) BACE1CTSDBACE2MAPTALDH1A1
SCHEMBL5220541 0.82 KDM4E (0.44) BACE1CTSDBACE2MAPTALDH1A1
SCHEMBL5219019 0.81 CASR (0.41) CTSDALDH1A1HPGDLMNAMEN1
SCHEMBL5219027 0.81 CASR (0.41) CTSDALDH1A1HPGDLMNAMEN1
SCHEMBL5221255 0.79 USP2 (0.46) BACE1CTSDBACE2ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567488-B1 HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE GLAXO GROUP LTD (GB) 2007-02-21 EP disclosed