Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.40 |
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218781 | 1.00 | POLB (0.43) | POLBGAASMN1; SMN2EPHX1KDM4E | |
| SCHEMBL5224070 | 0.88 | EPHX2 (0.47) | GAAEPHX1KDM4EBACE1CTSD | |
| SCHEMBL5224084 | 0.88 | EPHX2 (0.47) | GAAEPHX1KDM4EBACE1CTSD | |
| SCHEMBL5220541 | 0.83 | KDM4E (0.44) | POLBSMN1; SMN2KDM4EBACE1CTSD | |
| SCHEMBL5220548 | 0.83 | KDM4E (0.44) | POLBSMN1; SMN2KDM4EBACE1CTSD | |
| SCHEMBL5221255 | 0.80 | USP2 (0.46) | SMN1; SMN2KDM4EBACE1CTSDBACE2 | |
| SCHEMBL5221262 | 0.80 | USP2 (0.46) | SMN1; SMN2KDM4EBACE1CTSDBACE2 | |
| SCHEMBL5223476 | 0.80 | BACE1 (0.44) | BACE1CTSDBACE2 | |
| SCHEMBL4693111 | 0.80 | BACE1 (0.41) | BACE1CTSDBACE2 | |
| SCHEMBL5223477 | 0.80 | BACE1 (0.44) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |