Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224403 | 0.88 | POLB (0.45) | POLBHCAR3TP53 | |
| SCHEMBL5219935 | 0.88 | ALDH1A1 (0.34) | — | |
| SCHEMBL5219484 | 0.79 | BACE1 (0.44) | POLBHCAR3HTT | |
| SCHEMBL5219941 | 0.76 | POLB (0.37) | POLBTP53 | |
| SCHEMBL5219833 | 0.75 | BACE1 (0.41) | POLBHCAR3TP53HTT | |
| SCHEMBL5219381 | 0.74 | GPR35 (0.37) | POLBHCAR3TP53 | |
| SCHEMBL5224501 | 0.73 | POLB (0.36) | POLB | |
| SCHEMBL5217639 | 0.72 | CTSD (0.37) | POLB | |
| SCHEMBL5218643 | 0.70 | DRD2 (0.35) | POLB | |
| SCHEMBL5223926 | 0.70 | CTSD (0.36) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |