Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225502 | 0.88 | SSTR5 (0.37) | SSTR5ACHESCN9ASCN5ASCN10A | |
| SCHEMBL7256544 | 0.79 | DRD4 (0.44) | SSTR5ACHEDRD4DRD3MAPT | |
| SCHEMBL1689504 | 0.78 | SMO (0.45) | SSTR5ACHEDRD4DRD3HTT | |
| SCHEMBL5737789 | 0.77 | SMO (0.44) | SSTR5DRD4DRD3MAPTLMNA | |
| SCHEMBL5228638 | 0.76 | DRD4 (0.41) | SSTR5ACHEDRD4DRD3MAPT | |
| SCHEMBL7262021 | 0.75 | DRD4 (0.47) | SSTR5ACHEDRD4DRD3MAPT | |
| SCHEMBL5224217 | 0.75 | SMO (0.44) | SSTR5ACHESCN9ADRD4DRD3 | |
| SCHEMBL7261049 | 0.75 | CHKA (0.50) | SSTR5ACHEDRD4DRD3SMO | |
| SCHEMBL7261173 | 0.75 | SMO (0.47) | SSTR5DRD4DRD3MAPTSMO | |
| SCHEMBL5230137 | 0.74 | PTGS2 (0.43) | SSTR5DRD4DRD3SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |