Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835536 | 0.82 | FERMT2 (0.54) | SHMT2HTTPKMLMNARAB9A | |
| SCHEMBL30046801 | 0.82 | SHMT2 (0.45) | SHMT2HTTPKMLMNARAB9A | |
| SCHEMBL18208607 | 0.81 | KMT2A (0.44) | ALDH1A1POLBKMT2ATDP1KDM4E | |
| SCHEMBL5017658 | 0.81 | HDAC1 (0.47) | PIK3CA | |
| SCHEMBL13718267 | 0.81 | ADRA2B (0.38) | ALDH1A1POLBMEN1KMT2ATDP1 | |
| SCHEMBL13717709 | 0.81 | MAPT (0.44) | HTTLMNARAB9AALDH1A1POLB | |
| SCHEMBL1521870 | 0.80 | PKM (0.45) | SHMT2HTTPKMLMNARAB9A | |
| Hydrochloric Acid SCHEMBL5398554 | 0.79 | PIK3CA (0.54) | LMNAALDH1A1POLBMAPTMEN1 | |
| SCHEMBL14566065 | 0.79 | PKM (0.40) | SHMT2HTTPKMLMNARAB9A | |
| SCHEMBL2847441 | 0.77 | FERMT2 (0.43) | SHMT2HTTRAB9AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765817-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006002829-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |