Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4984503 | 0.86 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL14263394 | 0.85 | CYP3A4 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL14263316 | 0.85 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL5226399 | 0.84 | RAB9A (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL4982448 | 0.80 | MAPT (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL18960442 | 0.78 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL17487719 | 0.78 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL21660946 | 0.77 | ALDH1A1 (0.58) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL14263338 | 0.77 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2TP53LMNA | |
| SCHEMBL14263411 | 0.77 | MAPK1 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |