Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4984503 | 0.88 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL5228756 | 0.86 | LMNA (0.55) | SMN1; SMN2MAPK1LMNAKDM4ETP53 | |
| SCHEMBL14263316 | 0.86 | NPC1 (0.67) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL4980587 | 0.86 | HDAC6 (0.64) | RAB9ANPC1SMN1; SMN2MAPK1ALOX15 | |
| SCHEMBL14263394 | 0.86 | CYP3A4 (0.54) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL14263411 | 0.86 | MAPK1 (0.53) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL14263338 | 0.86 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL5225740 | 0.84 | NPC1 (0.61) | RAB9ANPC1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL14263326 | 0.82 | SMN1; SMN2 (0.72) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL12413898 | 0.80 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |