Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14431632 | 0.87 | POLB (0.42) | POLBL3MBTL1KMT2AMEN1PLK1 | |
| SCHEMBL3941374 | 0.85 | L3MBTL1 (0.48) | POLBAKR1C3AKR1C2AKR1C1L3MBTL1 | |
| SCHEMBL3942070 | 0.83 | L3MBTL1 (0.45) | POLBAKR1C3AKR1C2AKR1C1L3MBTL1 | |
| SCHEMBL11733684 | 0.82 | NTSR1 (0.56) | POLBL3MBTL1CYP2C9CYP2C19KMT2A | |
| SCHEMBL5224473 | 0.81 | AKR1C3 (0.45) | POLBAKR1C3AKR1C2AKR1C1L3MBTL1 | |
| SCHEMBL11753507 | 0.78 | AKR1C3 (0.49) | POLBAKR1C3AKR1C2AKR1C1CYP2C9 | |
| SCHEMBL11749450 | 0.78 | AKR1C3 (0.49) | POLBAKR1C3AKR1C2AKR1C1CYP2C9 | |
| SCHEMBL7090969 | 0.78 | AKR1C3 (0.49) | POLBAKR1C3AKR1C2AKR1C1CYP2C9 | |
| SCHEMBL14507322 | 0.78 | AKR1C3 (0.49) | POLBAKR1C3AKR1C2AKR1C1CYP2C9 | |
| SCHEMBL7843939 | 0.77 | AKR1C3 (0.48) | POLBAKR1C3AKR1C2AKR1C1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |