Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226178 | 0.85 | AAK1 (0.31) | AAK1 | |
| SCHEMBL5230515 | 0.83 | DRD4 (0.30) | — | |
| SCHEMBL5225271 | 0.81 | DRD4 (0.34) | KDM4E | |
| SCHEMBL5225926 | 0.78 | MCHR1 (0.41) | TP53AAK1LMNAMAPTTHRB | |
| SCHEMBL2901963 | 0.74 | ABCB1 (0.36) | MAPTKDM4E | |
| SCHEMBL5907258 | 0.69 | CYP2A13 (0.37) | F2F10 | |
| SCHEMBL5224327 | 0.68 | KDM4E (0.36) | TP53LMNAMAPTKDM4E | |
| SCHEMBL5224513 | 0.68 | KDM4E (0.36) | TP53LMNAMAPTKDM4E | |
| SCHEMBL2908338 | 0.68 | ALDH1A1 (0.37) | LMNAF2F10MAPTKDM4E | |
| SCHEMBL2904995 | 0.67 | ALDH1A1 (0.38) | PARP1PARP2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |