Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.38 |
| ▸ | KDM6A | O15550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226715 | 0.81 | ALDH1A1 (0.37) | MCHR1MAPTTP53LMNAUSP2 | |
| SCHEMBL5230509 | 0.80 | POLB (0.41) | TP53ALDH1A1SMN1; SMN2PDCD1CD274 | |
| SCHEMBL5225931 | 0.78 | TP53 (0.33) | MAPTTP53LMNAAAK1THRB | |
| SCHEMBL5229335 | 0.78 | ALDH1A1 (0.42) | MCHR1MAPTTP53LMNAUSP2 | |
| SCHEMBL5226166 | 0.76 | ALDH1A1 (0.41) | MAPTTP53LMNAUSP2ALDH1A1 | |
| SCHEMBL5225937 | 0.73 | KDM4D (0.49) | KDM4DKDM6A | |
| SCHEMBL5225463 | 0.72 | ALDH1A1 (0.41) | MAPTTP53LMNAUSP2ALDH1A1 | |
| SCHEMBL21397260 | 0.70 | MAPT (0.47) | MAPTKDM4D | |
| SCHEMBL13849470 | 0.69 | MCHR1 (0.70) | MCHR1 | |
| SCHEMBL17981132 | 0.68 | AKT1 (0.43) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611122-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MERCK PATENT GMBH (DE) | 2007-06-13 | — | — | EP | disclosed |