Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223926 | 0.97 | CTSD (0.36) | CTSDBACE1BACE2TSHRHTR7 | |
| SCHEMBL5226007 | 0.89 | POLB (0.39) | CTSDBACE1BACE2HTR7POLB | |
| SCHEMBL5217430 | 0.87 | ALDH1A1 (0.35) | CTSDBACE1BACE2POLB | |
| SCHEMBL5223919 | 0.85 | POLB (0.44) | CTSDBACE1BACE2TSHRHTR7 | |
| SCHEMBL5225333 | 0.84 | ALDH1A1 (0.35) | CTSDBACE1BACE2POLB | |
| SCHEMBL5379600 | 0.79 | TSHR (0.40) | TSHR | |
| SCHEMBL5220055 | 0.77 | BACE1 (0.36) | CTSDBACE1BACE2 | |
| SCHEMBL5221504 | 0.77 | CTSD (0.51) | CTSDBACE1BACE2 | |
| SCHEMBL5217435 | 0.76 | ALDH1A1 (0.39) | POLB | |
| SCHEMBL5220400 | 0.76 | BACE1 (0.55) | CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |