Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HK1 | P19367 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223501 | 0.86 | TRPA1 (0.44) | MAPTLMNAALDH1A1ALOX12HTT | |
| SCHEMBL5222047 | 0.84 | SYK (0.42) | MAPTALDH1A1ALOX15ALOX12HTT | |
| SCHEMBL5226799 | 0.82 | SYK (0.44) | MAPTTHRBLMNAALDH1A1ALOX12 | |
| SCHEMBL5223530 | 0.81 | MAPK14 (0.46) | MAPTALDH1A1ALOX12HTTTRPA1 | |
| SCHEMBL5221631 | 0.78 | SYK (0.42) | MAPTTHRBALDH1A1ALOX12HTT | |
| SCHEMBL5221924 | 0.75 | GSK3A (0.46) | MAPTGSK3AGSK3BLMNATP53 | |
| SCHEMBL5227456 | 0.73 | MAPT (0.40) | MAPTTP53ALDH1A1ALOX12HTT | |
| SCHEMBL5222107 | 0.71 | PTGS1 (0.39) | GSK3AGSK3BTRPA1MAPK14PTGS2 | |
| SCHEMBL5224063 | 0.70 | SOAT1 (0.42) | MAPTTHRBLMNATP53ALDH1A1 | |
| SCHEMBL5228063 | 0.70 | KMT2A (0.40) | MAPTALDH1A1ALOX12HTTCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |