Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222119 | 0.82 | KMT2A (0.44) | LMNATP53ALDH1A1MAPTMEN1 | |
| SCHEMBL5225894 | 0.78 | DYRK1A (0.44) | LMNAALDH1A1HTTALOX12MAPT | |
| SCHEMBL5221958 | 0.77 | ALDH1A1 (0.51) | LMNAALDH1A1HTTMAPTHPGD | |
| SCHEMBL5226884 | 0.76 | MAPK14 (0.50) | KDM4ENPC1RAB9A | |
| SCHEMBL5223759 | 0.76 | HPGD (0.49) | GSK3AGSK3BLMNATP53ALDH1A1 | |
| SCHEMBL5226058 | 0.75 | MAPT (0.44) | GSK3AGSK3BLMNATP53ALDH1A1 | |
| SCHEMBL2880935 | 0.70 | ABL1 (0.43) | TP53MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3335308 | 0.69 | HSD17B1 (0.56) | GSK3AGSK3BLMNATP53ALDH1A1 | |
| SCHEMBL1167596 | 0.69 | MAPT (0.56) | GSK3AGSK3BLMNATP53ALDH1A1 | |
| SCHEMBL30627606 | 0.69 | PKM (0.54) | LMNATP53ALDH1A1HTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |