Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226454 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| Hydrochloric Acid SCHEMBL5221824 | 0.77 | ALDH1A1 (0.35) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL5223471 | 0.73 | ADRB1 (0.38) | — | |
| SCHEMBL26707681 | 0.65 | PTGS1 (0.54) | ALDH1A1 | |
| SCHEMBL26620752 | 0.65 | PTGS1 (0.54) | ALDH1A1 | |
| SCHEMBL4956554 | 0.65 | ALDH1A1 (0.49) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL30471428 | 0.64 | KMT2A (0.41) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL27725653 | 0.62 | KMT2A (0.40) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL31498246 | 0.62 | ALDH1A1 (0.54) | ALDH1A1MAPTKMT2APOLBMEN1 | |
| SCHEMBL7050054 | 0.62 | DNM1 (0.47) | ALDH1A1KMT2APOLBMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |