Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226589 | 0.91 | NPC1 (0.68) | ESR1ESR2ALDH1A1NPC1RAB9A | |
| SCHEMBL11828034 | 0.87 | ALDH1A1 (0.71) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL4032178 | 0.85 | MAPT (0.60) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL18726342 | 0.85 | RAB9A (0.69) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL28559369 | 0.85 | SMN1; SMN2 (0.66) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL12639220 | 0.84 | NPC1 (0.68) | ESR1ESR2ALDH1A1NPC1RAB9A | |
| SCHEMBL9858278 | 0.84 | HDAC6 (0.58) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL11138585 | 0.84 | HDAC6 (0.58) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL1024034 | 0.84 | HSD17B10 (0.78) | ALDH1A1NPC1RAB9AMAPTHDAC6 | |
| SCHEMBL4476460 | 0.82 | ESR1 (1.00) | ESR1ESR2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070208066-A1 | ER-beta-selective ligands | BARLAAM BERNARD | 2007-09-06 | — | — | US | disclosed |
| US-20070208066-A1 | ER-beta-selective ligands | BARLAAM BERNARD | 2007-09-06 | — | — | US | disclosed |
| US-20070208066-A1 | ER-beta-selective ligands | BARLAAM BERNARD | 2007-09-06 | — | — | US | disclosed |
| US-20060111408-A1 | Therapeutic benzothiazole compounds | BARLAAM BERNARD | 2006-05-25 | — | — | US | disclosed |
| US-7045539-B2 | Therapeutic benzoxazole compounds | ASTRAZENECA AB (SE) | 2006-05-16 | — | — | US | disclosed |
| US-20040102435-A1 | Therapeutic compounds | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | US | disclosed |
| EP-1345914-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051821-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |
| US-4418002-A | Melamine group containing ultraviolet stabilizers and their use in organic compositions II | EASTMAN KODAK COMPANY (US) | 1983-11-29 | — | — | US | disclosed |
| US-4418001-A | Melamine group containing ultraviolet stabilizers and their use in organic compositions III | EASTMAN KODAK COMPANY (US) | 1983-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102435-A1 | Therapeutic compounds | ESRRA, ESRRG, ESR2 | ESR1 6/4885ESR2 3/4885ALDH1A1 484/4885 |
| US-20070208066-A1 | ER-beta-selective ligands | ESR2, ESRRG, ESRRA | ESR1 5/4885ESR2 1/4885ALDH1A1 1377/4885 |
| US-20060111408-A1 | Therapeutic benzothiazole compounds | ESR1, ESR2, ESRRG | ESR1 1/4885ESR2 2/4885ALDH1A1 501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.