Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335061 | 0.85 | KDM4E (0.61) | LMNAALDH1A1KMT2AMEN1POLB | |
| SCHEMBL12306045 | 0.84 | LMNA (0.48) | LMNAALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL10876210 | 0.84 | GFER (0.65) | LMNAALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL6334379 | 0.83 | LMNA (0.47) | LMNAALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL6334381 | 0.83 | LMNA (0.47) | LMNAALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL3028108 | 0.82 | MAPT (0.69) | LMNAALDH1A1KMT2AMEN1POLB | |
| SCHEMBL632099 | 0.81 | LMNA (0.68) | LMNAALDH1A1HSP90AA1KMT2AMEN1 | |
| SCHEMBL4129285 | 0.81 | MAPT (0.61) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL62896 | 0.80 | NPC1 (0.63) | LMNAALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3466014 | 0.79 | TDP1 (0.64) | LMNAALDH1A1MAPTHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101018770-A | PGD2 receptor antagonists for the treatment of inflammatory diseases | MILLENNIUM PHARM INC (US) | 2007-08-15 | — | — | CN | disclosed |
| EP-1799663-A1 | MODULATORS OF HCV REPLICATION | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038039-A1 | MODULATORS OF HCV REPLICATION | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2006-04-13 | — | — | WO | disclosed |