Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.55 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL27741256 | 0.89 | MAPT (0.57) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL17669252 | 0.89 | MAPT (0.71) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL15801114 | 0.89 | MAPT (0.71) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL1483566 | 0.87 | MAPT (0.71) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL9531913 | 0.85 | NPC1 (0.68) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL335061 | 0.85 | KDM4E (0.61) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL4976412 | 0.84 | LMNA (0.52) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL1484133 | 0.84 | MAPT (0.67) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL1372140 | 0.84 | MAPT (0.66) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL1481892 | 0.83 | POLB (0.72) | MAPTALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | claimed |
| US-9688696-B2 | Piperidine/piperazine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-06-27 | — | — | US | disclosed |
| US-20170029440-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-02-02 | — | — | US | disclosed |
| US-9499567-B2 | Piperidine/piperazine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-11-22 | — | — | US | disclosed |
| US-20150322088-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-11-12 | — | — | US | disclosed |
| EP-2152271-B1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-21 | — | — | EP | disclosed |
| US-9120821-B2 | Piperidine/piperazine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-09-01 | — | — | US | disclosed |
| US-20140350012-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2014-11-27 | — | — | US | disclosed |
| US-8835437-B2 | Piperidine/piperazine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-09-16 | — | — | US | disclosed |
| CN-101448802-B | Acrylamide derivative as histone deacetylase inhibitors for cancer treatment | DAC SRL | 2012-11-07 | — | — | CN | disclosed |
| US-20100216809-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-26 | — | — | US | disclosed |
| EP-2152271-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | Janssen Pharmaceutica, N.V. (BE) | 2010-02-17 | — | — | EP | disclosed |
| CN-101448802-A | N-hydroxy-3-(4-{3-phenyl-S-oxo-propenyl}-phenyl)-acrylamide derivatives and related compounds as histone deacetylase inhibitors for the treatment of cancer | DAC SRL (IT) | 2009-06-03 | — | — | CN | disclosed |
| WO-2008148840-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-12-11 | — | — | WO | disclosed |
| CN-1326519-C | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2007-07-18 | — | — | CN | disclosed |
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216809-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | DGAT1, DGAT2, DLAT | MAPT 2039/4885ALDH1A1 488/4885KMT2A 825/4885 |
| US-20170029440-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | DGAT1, PAOX, DGAT2 | MAPT 2270/4885ALDH1A1 590/4885KMT2A 1091/4885 |
| US-20140350012-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | DGAT1, PAOX, NNT | MAPT 2026/4885ALDH1A1 629/4885KMT2A 1208/4885 |
| US-20150322088-A1 | PIPERIDINE/PIPERAZINE DERIVATIVES | DGAT1, PAOX, DGAT2 | MAPT 2270/4885ALDH1A1 590/4885KMT2A 1091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.