Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225491 | 0.89 | SLC2A1 (0.41) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL5225154 | 0.86 | SLC2A1 (0.46) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL5229307 | 0.85 | SLC2A1 (0.44) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL3441833 | 0.78 | MAPK1 (0.43) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL5227240 | 0.77 | SLC2A1 (0.54) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL3434367 | 0.77 | JAK2 (0.35) | AURKBGSK3BMAPK8MAPK9MAPK1 | |
| SCHEMBL3442012 | 0.77 | SLC2A1 (0.55) | SLC2A1AURKAKDRAURKBCDK19 | |
| SCHEMBL8808262 | 0.76 | GSK3B (0.49) | GSK3BADORA1MAPK14EGFRRAF1 | |
| SCHEMBL3421116 | 0.76 | MAPK14 (0.37) | AURKBGSK3BMAPK14MAPK8MAPK9 | |
| SCHEMBL5223864 | 0.75 | SLC2A1 (0.42) | SLC2A1AURKAKDRAURKBCDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | disclosed |