Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 5/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3434367 | 0.85 | JAK2 (0.35) | CDC7JAK2CDK2DBF4CCNE1 | |
| SCHEMBL1642029 | 0.76 | CDK2 (0.48) | MAPK14BRAFCDK2CCNE1CDK4 | |
| SCHEMBL5226662 | 0.76 | SLC2A1 (0.41) | MAPK14MAPK1MAPK8MAPK9GSK3B | |
| SCHEMBL1640558 | 0.75 | LCLAT1 (0.45) | MAPK14BRAFCDK2CDK4 | |
| SCHEMBL3422428 | 0.75 | MAPK14 (0.48) | MAPK14CDK2CDK4 | |
| SCHEMBL3434769 | 0.74 | BRAF (0.35) | CDC7BRAFJAK2CDK2DBF4 | |
| SCHEMBL1641904 | 0.73 | BRAF (0.51) | MAPK14BRAFCDK2CDK4 | |
| SCHEMBL3421110 | 0.72 | MAPK14 (0.34) | MAPK14BRAFCDK2CDK4 | |
| SCHEMBL31111557 | 0.72 | CDK2 (0.41) | BRAFJAK2CDK2CCNE1CDK4 | |
| SCHEMBL30410597 | 0.72 | PTGS2 (0.51) | CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231625-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |