Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | CDC7 | O00311 | 6/20 | 0.35 |
| ▸ | RORB | Q92753 | 3/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.32 |
| ▸ | KMO | O15229 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421116 | 0.85 | MAPK14 (0.37) | JAK2CDC7SCN9ACDK2DBF4 | |
| SCHEMBL5226662 | 0.77 | SLC2A1 (0.41) | SCN9AGSK3BMAPK1MAPK8MAPK9 | |
| SCHEMBL1640422 | 0.75 | CAMK2D (0.42) | CDK2CDK9DYRK3PRKACACDK5 | |
| SCHEMBL1642023 | 0.74 | LCLAT1 (0.47) | MAPK1LMNA | |
| SCHEMBL31111547 | 0.73 | KMO (0.36) | CDC7SCN9ACDK2DBF4CCNE1 | |
| SCHEMBL13816258 | 0.73 | RORB (0.33) | RORBRORCKMO | |
| SCHEMBL1641900 | 0.72 | MAPT (0.47) | JAK2GSK3BTAOK1PRKD3CHEK2 | |
| SCHEMBL1641438 | 0.71 | GPBAR1 (0.39) | RORBRORC | |
| SCHEMBL3434366 | 0.71 | — | — | |
| SCHEMBL31111793 | 0.71 | KMO (0.33) | JAK2CDK2KMOCDK1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231625-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |