Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224015 | 0.83 | SLC6A4 (0.35) | MAPK14PTGS1 | |
| SCHEMBL5223501 | 0.78 | TRPA1 (0.44) | MAPK14 | |
| SCHEMBL5222107 | 0.76 | PTGS1 (0.39) | PTGS2MAPK14PTGS1 | |
| SCHEMBL5225534 | 0.74 | PTGS2 (0.58) | PTGS2MAPK14PTGS1 | |
| SCHEMBL5226799 | 0.74 | SYK (0.44) | MAPK14 | |
| SCHEMBL5223948 | 0.73 | PTGS2 (0.56) | PTGS2MAPK14PTGS1 | |
| SCHEMBL5223530 | 0.73 | MAPK14 (0.46) | MAPK14 | |
| SCHEMBL5222047 | 0.72 | SYK (0.42) | PTGS2MAPK14 | |
| SCHEMBL5221631 | 0.71 | SYK (0.42) | MAPK14 | |
| SCHEMBL3943716 | 0.71 | PTGS2 (0.49) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300399-B1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2007-08-22 | — | — | EP | disclosed |
| US-6664256-B1 | Interleukin- 1 beta inhibitors | KOWA CO., LTD. (JP) | 2003-12-16 | — | — | US | disclosed |
| EP-1300399-A1 | PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |