Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 3/20 | 0.56 |
| ▸ | ADORA1 known ✓ | P30542 | 2/20 | 0.56 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.56 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.56 |
| ▸ | GAPDH | P04406 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | STAT6 | P42226 | 1/20 | 0.56 |
| ▸ | PI4KA | P42356 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.56 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.56 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL3429274 | 0.92 | ADORA3 (0.66) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL3427102 | 0.89 | ADORA3 (0.70) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL15753116 | 0.88 | ADORA3 (0.56) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL21854749 | 0.86 | ADORA3 (0.54) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL16319999 | 0.85 | ADORA3 (0.56) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Inosine SCHEMBL28379793 | 0.85 | ADORA3 (0.55) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL27813101 | 0.84 | ADORA3 (0.74) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL28574438 | 0.84 | ADORA3 (0.61) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Adenosine SCHEMBL9736217 | 0.82 | ADORA3 (0.59) | ADORA3DOT1LADORA1DPP4MEN1 | |
| Guanosine SCHEMBL8995759 | 0.82 | HPGD (0.62) | ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824532-A2 | MEDICAL DEVICES AND COMPOSITIONS FOR TREATING RESTENOSIS | Medtronic Vascular, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006052521-A2 | MEDICAL DEVICES AND COMPOSITIONS FOR TREATING RESTENOSIS | MEDTRONIC VASCULAR, INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20060099235-A1 | Medical devices and compositions useful for treating or inhibiting restenosis | MEDTRONIC VASCULAR, INC. (US) | 2006-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060099235-A1 | Medical devices and compositions useful for treating or inhibiting restenosis | IKBKG, IKBKB, IKBKE | ADORA3 4340/4885ADORA1 3202/4885ADORA2A 3928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.