Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 8/20 | 0.31 |
| ▸ | HTR2C | P28335 | 8/20 | 0.31 |
| ▸ | DRD2 | P14416 | 7/20 | 0.31 |
| ▸ | HRH1 | P35367 | 7/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.31 |
| ▸ | DRD1 | P21728 | 6/20 | 0.31 |
| ▸ | DRD3 | P35462 | 6/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.31 |
| ▸ | DRD4 | P21917 | 4/20 | 0.31 |
| ▸ | HTR7 | P34969 | 4/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.31 |
| ▸ | HTR1A | P08908 | 4/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226637 | 0.96 | MAPK1 (0.34) | MAPK1CXCR1HTR2AHTR2CDRD2 | |
| SCHEMBL5229959 | 0.92 | CACNA1H (0.33) | CXCR1DRD2ADRA2ADRD1DRD3 | |
| SCHEMBL5226966 | 0.87 | NPC1 (0.32) | HTR7ADRB2CACNA1HCACNA1BMAOA | |
| SCHEMBL4695749 | 0.85 | MAPK1 (0.32) | MAPK1CXCR1ADRA2ADRD1DRD3 | |
| SCHEMBL5225145 | 0.84 | MAPK1 (0.37) | MAPK1HTR2AHTR2CDRD2HRH1 | |
| SCHEMBL4692968 | 0.84 | MAPK1 (0.32) | MAPK1CXCR1ADRA2ADRD1DRD3 | |
| SCHEMBL5227049 | 0.81 | CYP1A2 (0.34) | MAPK1CXCR1HTR2AHTR2CDRD2 | |
| SCHEMBL4694428 | 0.80 | MAPK1 (0.33) | MAPK1HTR2AHTR2CDRD2HRH1 | |
| SCHEMBL3887203 | 0.80 | MAPK1 (0.33) | MAPK1CXCR1HTR2AHTR2CDRD2 | |
| SCHEMBL3883586 | 0.79 | ADRA1A (0.32) | MAPK1HRH1ADRA1AHRH3ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312203-B2 | 1-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | GlaxoSmithKline istraziva{hacek over (c)}ki Centar Zagreb d.o.o. (HR) | 2007-12-25 | — | — | US | claimed |
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | claimed |
| US-20070111968-A1 | 1-Aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2007-05-17 | — | — | US | claimed |
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-09-22 | — | — | US | claimed |
| EP-1506202-B1 | 1-AZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2007-08-08 | — | — | EP | disclosed |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111968-A1 | 1-Aza-dibenzo[e,h]azulenes for the treatment of central nervous system diseases and disorders | DBH, BCHE, DDT | MAPK1 2673/4885CXCR1 1246/4885HTR2A 152/4885 |
| US-20050209191-A1 | 1-Aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | MAPK1 207/4885CXCR1 235/4885HTR2A 4687/4885 |
| US-20050148578-A1 | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof | TNF, IL1A, IL1B | MAPK1 223/4885CXCR1 249/4885HTR2A 4707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.