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SCHEMBL5227898

SCHEMBL5227898

CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN2C(=O)N(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1

nearest known ligand 0.45

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ GHSR Q92847 8/20 0.45
▸ HPGD P15428 1/20 0.32
▸ ALOX15 P16050 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ SCD O00767 1/20 0.32
▸ PSMB5 P28074 1/20 0.32
▸ TGM2 P21980 2/20 0.32
▸ MMP1 P03956 1/20 0.32
▸ MMP3 P08254 1/20 0.32
▸ MMP9 P14780 1/20 0.32
▸ NR3C2 P08235 2/20 0.32
▸ F2 P00734 1/20 0.32
▸ F10 P00742 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5224946 1.00 GHSR (0.45) GHSRHPGDALOX15TDP1SCD
Hydrochloric Acid SCHEMBL7687555 0.99 GHSR (0.45) GHSRHPGDALOX15TDP1SCD
SCHEMBL5229201 0.89 GHSR (0.38) GHSRTGM2MMP1MMP3MMP9
SCHEMBL3840114 0.89 GHSR (0.55) GHSR
SCHEMBL5224961 0.89 GHSR (0.55) GHSR
SCHEMBL7679198 0.86 GHSR (0.49) GHSR
SCHEMBL5225623 0.84 GHSR (0.53) GHSR
SCHEMBL5224876 0.84 GHSR (0.53) GHSR
SCHEMBL7617779 0.82 GHSR (0.33) GHSR
SCHEMBL5226469 0.82 GHSR (0.56) GHSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001970-B1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER (US) 2007-03-07 — — EP claimed
US-6887281-B2 N-heteroarylmethyl-p-phenylenediamine derivatives as well as oxidation dyeing agents containing these compounds WELLA AKTIENGESELLSCHAFT (DE) 2005-05-03 — — US claimed
US-20050015898-A1 N-heteroarylmethyl-p-phenylenediamine derivatives as well as oxidation dyeing agents containing these compounds HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2005-01-27 — — US claimed
US-20040009984-A1 Increasing levels of endogenous growth hormone, especially treating osterporosis, aging frailty or congestive heart failure CARPINO PHILIP ALBERT (US) 2004-01-15 — — US claimed
US-20040006063-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2004-01-08 — — US claimed
US-20030216399-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2003-11-20 — — US claimed
US-20020065284-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-05-30 — — US claimed
US-20020042415-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-04-11 — — US claimed
US-20020002165-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2002-01-03 — — US claimed
US-20010041703-A1 Dipeptide derivatives CARPINO PHILIP ALBERT (US) 2001-11-15 — — US claimed
EP-1001970-A1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER INC. (US) 2000-05-24 — — EP claimed
WO-1998058947-A1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER INC. (US) 1998-12-30 — — WO claimed
EP-1001970-B1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER (US) 2007-03-07 — — EP disclosed
US-6953791-B2 Dipeptide derivatives PFIZER, INC. (US) 2005-10-11 — — US disclosed
US-6951850-B2 Dipeptide derivatives PFIZER, INC. (US) 2005-10-04 — — US disclosed
US-6924280-B2 Dipeptide derivatives PFIZER INC. (US) 2005-08-02 — — US disclosed
US-6251902-B1 Dipeptide derivatives as growth hormone secretagogues PFIZER INC. 2001-06-26 — — US disclosed
WO-2001008644-A1 HAIR CONDITIONING COMPOSITION COMPRISING HYDROPHOBICALLY MODIFIED CELLULOSE ETHER THE PROCTER & GAMBLE COMPANY (US) 2001-02-08 — — WO disclosed
EP-1001970-A1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER INC. (US) 2000-05-24 — — EP disclosed
WO-1998058947-A1 DIPEPTIDE DERIVATIVES AS GROWTH HORMONE SECRETAGOGUES PFIZER INC. (US) 1998-12-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040009984-A1 Increasing levels of endogenous growth hormone, especially treating osterporosis, aging frailty or congestive heart failure GHSR, GHRHR, GIPR GHSR 1/4885HPGD 1116/4885ALOX15 912/4885
US-20020042415-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885HPGD 1140/4885ALOX15 1341/4885
US-20010041703-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885HPGD 1114/4885ALOX15 1944/4885
US-20020002165-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885HPGD 1140/4885ALOX15 1341/4885
US-20040006063-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885HPGD 1074/4885ALOX15 1163/4885
US-20030216399-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885HPGD 1140/4885ALOX15 1341/4885
US-20020065284-A1 Dipeptide derivatives GIPR, GHRHR, GHSR GHSR 3/4885HPGD 1140/4885ALOX15 1341/4885
US-20050015898-A1 N-heteroarylmethyl-p-phenylenediamine derivatives as well as oxidation dyeing agents containing these compounds TYR, PNMT, DDT GHSR 4479/4885HPGD 284/4885ALOX15 1466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.