SCHEMBL5228401

SCHEMBL5228401

CCOC(=O)CN(Cc1ccc(OCc2nc(-c3ccccc3)oc2C(C)C)cc1)S(=O)(=O)N(C)C

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARG P37231 16/20 0.47
PPARA Q07869 14/20 0.47
FFAR1 O14842 1/20 0.46
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
TP53 P04637 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
HSD17B10 Q99714 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5228595 0.91 FFAR1 (0.57) PPARGPPARAFFAR1
SCHEMBL5228786 0.91 PPARA (0.51) PPARGPPARAFFAR1
SCHEMBL5437130 0.85 PPARG (0.64) PPARGPPARA
SCHEMBL5228982 0.84 PPARG (0.55) PPARGPPARAFFAR1TP53MAPT
SCHEMBL5232928 0.84 FFAR1 (0.54) PPARGPPARAFFAR1
SCHEMBL5224993 0.82 KDR (0.58) PPARGPPARA
SCHEMBL5223600 0.82 FFAR1 (0.63) PPARGPPARAFFAR1
SCHEMBL14361101 0.82 PPARA (0.53) PPARGPPARA
SCHEMBL5231084 0.81 PPARG (0.47) PPARGPPARAFFAR1MAPT
SCHEMBL5229727 0.81 PPARG (0.51) PPARGPPARAFFAR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same CRYSTAL GENOMICS, INC. (KR) 2007-11-01 US disclosed
EP-1778654-A1 SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME Crystalgenomics, Inc. (KR) 2007-05-02 EP disclosed
WO-2006006832-A1 SULFAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR UPREGULATION OF LIPID METABOLISM COMPRISING SAME CRYSTALGENOMICS, INC. (KR) 2006-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254882-A1 Sulfamide Derivatives and Pharmaceutical Composition for Upregulation of Lipid Metabolism Comprising Same SULT2A1, SPTLC2, SGMS2 PPARG 399/4885PPARA 190/4885FFAR1 159/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.