Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | POLB | P06746 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895870 | 0.78 | MAPT (0.68) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL2761209 | 0.76 | BCL2L1 (0.56) | — | |
| SCHEMBL5233339 | 0.74 | CYP2A6 (0.54) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL13295761 | 0.73 | MAPT (0.71) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL8800681 | 0.71 | IKBKB (0.39) | MAPTKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL16335038 | 0.71 | MAPT (0.71) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL7534418 | 0.69 | ALDH1A1 (0.42) | MAPTKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8127607 | 0.69 | ALDH1A1 (0.43) | MAPTKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6564086 | 0.69 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1GAASMN1; SMN2 | |
| Acridine SCHEMBL8643076 | 0.68 | ALDH1A1 (0.68) | MAPTKDM4EALDH1A1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461335-B1 | 2-HETEROARYLCARBOXYLIC ACID AMIDES | BAYER HEALTHCARE AG (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1461335-A1 | 2-HETEROARYLCARBOXYLIC ACID AMIDES | Bayer HealthCare AG (DE) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003055878-A1 | 2-HETEROARYLCARBOXYLIC ACID AMIDES | BAYER HEALTHCARE AG (DE) | 2003-07-10 | — | — | WO | disclosed |