Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GLA | P06280 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127607 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL18795133 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL6563671 | 0.79 | KDM4C (0.48) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL377125 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDMAPTMGAM | |
| SCHEMBL6567448 | 0.79 | TLR8 (0.53) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL6567506 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL27910966 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL16654428 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAHPGDSTAT3 | |
| SCHEMBL6036781 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAHPGDMAPT | |
| SCHEMBL6564049 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDGLAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |