Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233178 | 0.93 | SCN8A (0.55) | MEN1KMT2AKDM4ETDP1SCN8A | |
| SCHEMBL6991255 | 0.87 | CACNA1H (0.46) | MEN1KMT2AKDM4ETDP1PDCD1 | |
| SCHEMBL18198086 | 0.85 | CTSS (0.54) | MEN1KMT2ASCN8APDCD1CD274 | |
| SCHEMBL17687214 | 0.85 | PHGDH (0.46) | MEN1KMT2ASCN8APDCD1CD274 | |
| SCHEMBL28929817 | 0.84 | HDAC1 (0.51) | MEN1KMT2AKDM4ETDP1CYP1A2 | |
| SCHEMBL22452352 | 0.84 | POLB (0.53) | KDM4EPDCD1CD274CYP3A4CYP2D6 | |
| SCHEMBL22452353 | 0.82 | CTSB (0.54) | KDM4EPDCD1CD274NPC1CYP1A2 | |
| SCHEMBL7107994 | 0.82 | KDM4E (0.54) | KDM4EPDCD1CD274NPC1RAB9A | |
| SCHEMBL31500361 | 0.82 | KDM4E (0.54) | KDM4EPDCD1CD274NPC1RAB9A | |
| SCHEMBL22605044 | 0.82 | ATM (0.58) | MEN1KMT2AKDM4ETDP1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496059-B1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2007-08-15 | — | — | EP | disclosed |
| CN-1330654-C | Fused bicyclic pyrimidine derivatives | KYORIN SEIYAKU KK (JP) | 2007-08-08 | — | — | CN | disclosed |
| US-7064119-B2 | Fused bicyclic pyrimidine derivatives | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2006-06-20 | — | — | US | disclosed |
| CN-1656098-A | Fused bicyclic pyrimidine derivatives | KYORIN SEIYAKU KK (JP) | 2005-08-17 | — | — | CN | disclosed |
| US-20050159409-A1 | Fused bicyclic pyrimidine derivatives | KYORIN PHARMACEUTICAL CO. LTD. (JP) | 2005-07-21 | — | — | US | disclosed |
| EP-1496059-A1 | FUSED BICYCLIC PYRIMIDINE DERIVATIVES | Kyorin Pharmaceutical Co., Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159409-A1 | Fused bicyclic pyrimidine derivatives | BDKRB1, BDKRB2, TACR1 | MEN1 770/4885KMT2A 1383/4885KDM4E 3321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.