Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 5/20 | 0.59 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.59 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11085032 | 0.86 | GABBR2 (0.62) | GABBR2GABBR1IDO1TDO2AOC3 | |
| SCHEMBL1772818 | 0.86 | GABBR2 (0.47) | GABBR2GABBR1IDO1TDO2AOC3 | |
| SCHEMBL5321547 | 0.83 | GABBR2 (0.56) | GABBR2GABBR1IDO1TDO2AOC3 | |
| SCHEMBL5327386 | 0.83 | GABBR2 (0.56) | GABBR2GABBR1IDO1TDO2AOC3 | |
| SCHEMBL11142937 | 0.80 | TAAR1 (0.56) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL7908792 | 0.78 | GABBR2 (0.42) | GABBR2GABBR1IDO1TDO2AOC3 | |
| SCHEMBL18595195 | 0.78 | TRPA1 (0.42) | GABBR2GABBR1AOC3LMNAMEN1 | |
| SCHEMBL9779274 | 0.78 | GABBR2 (0.61) | GABBR2GABBR1AOC3LMNACYP2C9 | |
| SCHEMBL2615282 | 0.78 | GABBR2 (0.55) | GABBR2GABBR1IDO1TDO2AOC3 | |
| SCHEMBL7396004 | 0.78 | GABBR2 (0.61) | GABBR2GABBR1AOC3LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765817-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006002829-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |