Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 5/20 | 0.56 |
| ▸ | GABBR1 | Q9UBS5 | 5/20 | 0.56 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321547 | 1.00 | GABBR2 (0.56) | GABBR2GABBR1AOC3IDO1TDO2 | |
| SCHEMBL28778319 | 0.87 | GABBR2 (0.44) | GABBR2GABBR1AOC3IDO1TDO2 | |
| SCHEMBL5230376 | 0.83 | GABBR2 (0.59) | GABBR2GABBR1AOC3IDO1TDO2 | |
| SCHEMBL7908792 | 0.83 | GABBR2 (0.42) | GABBR2GABBR1AOC3IDO1TDO2 | |
| SCHEMBL11085032 | 0.83 | GABBR2 (0.62) | GABBR2GABBR1AOC3IDO1TDO2 | |
| SCHEMBL24681122 | 0.80 | HTR2A (0.47) | GABBR2GABBR1LMNACYP2C9CYP3A4 | |
| SCHEMBL1835662 | 0.80 | ESR1 (0.40) | GABBR2GABBR1AOC3MEN1KMT2A | |
| SCHEMBL1959897 | 0.80 | ESR1 (0.40) | GABBR2GABBR1AOC3MEN1KMT2A | |
| SCHEMBL5404476 | 0.80 | GABBR2 (0.40) | GABBR2GABBR1AOC3IDO1TDO2 | |
| SCHEMBL1834790 | 0.80 | ESR1 (0.40) | GABBR2GABBR1AOC3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007136325-A1 | 1- [ (4- [BENZOYL (METHYL) AMINO] -3- (PHENYL) BUTYL] AZETIDINE DERIVATIVES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 2 | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |
| US-20070270400-A1 | New compounds 303 | ALBIREO AB (SE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270399-A1 | New compounds 302 | ALBIREO AB (SE) | 2007-11-22 | — | — | US | disclosed |
| US-20070270487-A1 | Novel process and intermediates 085 | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270400-A1 | New compounds 303 | CYP11B2, CYP11B1, SDHA | GABBR2 1419/4885GABBR1 1363/4885AOC3 1201/4885 |
| US-20070270487-A1 | Novel process and intermediates 085 | CYP3A5, AGPAT5, CYP4F8 | GABBR2 1606/4885GABBR1 1299/4885AOC3 1590/4885 |
| US-20070270399-A1 | New compounds 302 | CYP11B2, CYP11B1, CYP4B1 | GABBR2 887/4885GABBR1 1107/4885AOC3 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.