Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | HTT | P42858 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | SGK1 | O00141 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229199 | 0.85 | MAPT (0.68) | MAPTTP53HTTKMT2AMEN1 | |
| SCHEMBL26010796 | 0.83 | LMNA (0.62) | MAPTTP53HTTKMT2AMEN1 | |
| SCHEMBL5231184 | 0.83 | MAPT (0.68) | MAPTTP53HTTKMT2AMEN1 | |
| SCHEMBL1346862 | 0.80 | HTT (0.76) | MAPTTP53HTTKMT2AMEN1 | |
| SCHEMBL5231919 | 0.80 | MEN1 (0.60) | MAPTTP53HTTKMT2AMEN1 | |
| SCHEMBL5230621 | 0.78 | CES1 (0.50) | MAPTTP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL5230095 | 0.75 | PRMT1 (0.52) | MAPTTP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL5229246 | 0.75 | MEN1 (0.52) | MAPTTP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL5517767 | 0.74 | HPGD (0.54) | MAPTTP53HTTKMT2AMEN1 | |
| SCHEMBL24254327 | 0.74 | HPGD (0.58) | MAPTTP53HTTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |