Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231184 | 0.78 | MAPT (0.68) | MEN1KMT2ACES1MAPTGABRA1 | |
| SCHEMBL5237280 | 0.77 | CES1 (0.49) | MEN1KMT2ACES1MAPTALDH1A1 | |
| SCHEMBL5230722 | 0.75 | MAPT (0.69) | MEN1KMT2ACES1MAPTTP53 | |
| SCHEMBL5228629 | 0.75 | IDH1 (0.51) | MEN1KMT2ACES1MAPTALDH1A1 | |
| SCHEMBL5230316 | 0.74 | CES1 (0.49) | MEN1KMT2ACES1MAPTIDH1 | |
| SCHEMBL5230286 | 0.73 | IDH1 (0.48) | MEN1KMT2ACES1MAPTTP53 | |
| SCHEMBL17154 | 0.72 | KMT2A (0.40) | MEN1KMT2AMAPTALDH1A1TDP1 | |
| SCHEMBL5230151 | 0.72 | CES1 (0.73) | MEN1KMT2ACES1MAPTALDH1A1 | |
| SCHEMBL641243 | 0.72 | SMN1; SMN2 (0.64) | MEN1KMT2ACES1ALDH1A1IDH1 | |
| SCHEMBL23092462 | 0.71 | GAA (0.39) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |