Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.35 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5227844 | 0.90 | GSK3B (0.57) | GSK3BMAPTDAOTP53ERCC1 | |
| SCHEMBL5231030 | 0.89 | GSK3B (0.55) | GSK3BMAPTDAOTP53 | |
| SCHEMBL5231152 | 0.88 | GSK3B (0.55) | GSK3BMAPTTP53 | |
| SCHEMBL5229836 | 0.87 | GSK3B (0.52) | GSK3BMAPTDAOTP53HDAC3 | |
| SCHEMBL4855976 | 0.83 | GSK3B (1.00) | GSK3BMAPTTP53HDAC3HDAC4 | |
| SCHEMBL5234548 | 0.83 | MAPT (0.49) | GSK3BMAPTTP53 | |
| SCHEMBL5228636 | 0.82 | GSK3B (0.48) | GSK3BMAPTTP53 | |
| SCHEMBL5243212 | 0.79 | GSK3B (0.45) | GSK3BMAPTDAOTP53 | |
| SCHEMBL4848893 | 0.76 | GSK3B (0.86) | GSK3BMAPTTP53HDAC3HDAC4 | |
| SCHEMBL5235894 | 0.75 | GSK3B (0.57) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |