Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.37 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230770 | 0.90 | GSK3B (0.71) | GSK3BMAPTTP53DAOERCC1 | |
| SCHEMBL5231030 | 0.90 | GSK3B (0.55) | GSK3BMAPTTP53DAOALPL | |
| SCHEMBL5231152 | 0.89 | GSK3B (0.55) | GSK3BMAPTTP53 | |
| SCHEMBL5229836 | 0.89 | GSK3B (0.52) | GSK3BMAPTTP53DAOALPL | |
| SCHEMBL5234548 | 0.85 | MAPT (0.49) | GSK3BMAPTTP53 | |
| SCHEMBL5228636 | 0.84 | GSK3B (0.48) | GSK3BMAPTTP53ALPLMEN1 | |
| SCHEMBL4849862 | 0.82 | GSK3B (0.81) | GSK3BMAPTTP53ENPP2MEN1 | |
| SCHEMBL5243212 | 0.81 | GSK3B (0.45) | GSK3BMAPTTP53DAOMEN1 | |
| SCHEMBL5243973 | 0.77 | TSHR (0.48) | GSK3BMAPTDAO | |
| SCHEMBL5237798 | 0.75 | AKT3 (0.44) | GSK3BMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |