Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231030 | 0.90 | GSK3B (0.55) | GSK3BMAPTMEN1KMT2ATP53 | |
| SCHEMBL5229836 | 0.87 | GSK3B (0.52) | GSK3BMAPTMEN1KMT2ATP53 | |
| SCHEMBL5234548 | 0.85 | MAPT (0.49) | GSK3BMAPTTP53MAPK1ALDH1A1 | |
| SCHEMBL5227844 | 0.84 | GSK3B (0.57) | GSK3BMAPTMEN1KMT2ATP53 | |
| SCHEMBL5231152 | 0.83 | GSK3B (0.55) | GSK3BMAPTTP53 | |
| SCHEMBL5227662 | 0.82 | GSK3B (0.68) | GSK3BMAPTMEN1KMT2ATP53 | |
| SCHEMBL5230770 | 0.82 | GSK3B (0.71) | GSK3BMAPTTP53 | |
| SCHEMBL5243212 | 0.81 | GSK3B (0.45) | GSK3BMAPTMEN1KMT2ATP53 | |
| SCHEMBL5237798 | 0.77 | AKT3 (0.44) | GSK3BMAPTMEN1KMT2A | |
| SCHEMBL5234145 | 0.76 | DYRK1A (0.44) | GSK3BMAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581505-B1 | PYRIDAZINONE DERIVATIVES AS GSK-3BETA INHIBITORS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-08-01 | — | — | EP | claimed |