Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.57 |
| ▸ | CA1 | P00915 | 6/20 | 0.57 |
| ▸ | CA2 | P00918 | 6/20 | 0.57 |
| ▸ | CA9 | Q16790 | 6/20 | 0.57 |
| ▸ | CA7 | P43166 | 5/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20928662 | 0.92 | HRH3 (0.51) | CA12CA1CA2CA9CA7 | |
| SCHEMBL20929028 | 0.90 | CA12 (0.54) | CA12CA1CA2CA9CA7 | |
| SCHEMBL2453339 | 0.84 | TSHR (0.53) | CA12CA1CA2CA9CA7 | |
| SCHEMBL11805285 | 0.84 | CA12 (0.59) | CA12CA1CA2CA9CA7 | |
| SCHEMBL29843135 | 0.84 | CA12 (0.62) | CA12CA1CA2CA9CA7 | |
| SCHEMBL321387 | 0.84 | CA12 (0.62) | CA12CA1CA2CA9CA7 | |
| SCHEMBL3303156 | 0.81 | MAPK1 (0.55) | CA12CA1CA2CA9CA7 | |
| SCHEMBL485764 | 0.81 | TSHR (0.55) | CA12CA1CA2CA9CA7 | |
| SCHEMBL1238438 | 0.81 | CA12 (0.56) | CA12CA1CA2CA9CA7 | |
| SCHEMBL10570974 | 0.81 | CA12 (0.74) | CA12CA1CA2CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1262181-B1 | USE OF ISOTHIAZOLE DERIVATIVES AS UREASE INHIBITORS FOR THE TREATMENT OF HELICOBACTER PYLORI INDUCED GASTROINTESTINAL DISEASES | OTSUKA PHARMA CO LTD (JP) | 2007-05-16 | — | — | EP | disclosed |
| US-20040058952-A1 | Urease inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. | 2004-03-25 | — | — | US | disclosed |
| US-20030060482-A1 | Urease inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-27 | — | — | US | disclosed |
| EP-1262181-A1 | UREASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060482-A1 | Urease inhibitors | PGC, SLC14A1, USP1 | CA12 2815/4885CA1 1482/4885CA2 1356/4885 |
| US-20040058952-A1 | Urease inhibitors | PGC, SLC14A1, USP1 | CA12 2815/4885CA1 1482/4885CA2 1356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.