SCHEMBL5230830

SCHEMBL5230830

COC(=O)Oc1cc2cccc(OC)c2s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 2/20 0.51
CHRNA7 P36544 3/20 0.44
LMNA P02545 1/20 0.44
RECQL P46063 1/20 0.44
DYRK1A Q13627 1/20 0.43
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 2/20 0.43
HTR3A P46098 1/20 0.43
HPGDS O60760 1/20 0.43
HSD17B10 Q99714 3/20 0.42
KDM4E B2RXH2 3/20 0.42
HPGD P15428 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5234936 0.85 CA2 (0.53) CA2CHRNA7LMNARECQLALDH1A1
SCHEMBL5234682 0.83 CHRNA7 (0.41) CA2CHRNA7ALDH1A1KMT2AHTR3A
SCHEMBL5237282 0.83 HDAC3 (0.55) CHRNA7ALDH1A1HTR3AHSD17B10KDM4E
SCHEMBL5200826 0.83 CHRNA1 (0.40) CA2RECQLALDH1A1HSD17B10KDM4E
SCHEMBL5230188 0.79 HDAC3 (0.59) CHRNA7ALDH1A1KMT2AHTR3AKDM4E
SCHEMBL5232413 0.79 CHRNA7 (0.42) CA2CHRNA7ALDH1A1HTR3AHSD17B10
SCHEMBL9409696 0.78 KDM4E (0.48) CA2LMNAALDH1A1KMT2AHSD17B10
SCHEMBL5231955 0.78 MEN1 (0.51) LMNAALDH1A1KMT2AKDM4ERAB9A
SCHEMBL2895989 0.77 ALDH1A1 (0.55) CA2CHRNA7LMNARECQLALDH1A1
SCHEMBL5198179 0.77 HDAC3 (0.49) CA2LMNADYRK1AHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1461335-B1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-02-28 EP disclosed
EP-1461335-A1 2-HETEROARYLCARBOXYLIC ACID AMIDES Bayer HealthCare AG (DE) 2004-09-29 EP disclosed
WO-2003055878-A1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2003-07-10 WO disclosed