Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.39 |
| ▸ | PTAFR | P25105 | 7/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CLK1 | P49759 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230846 | 0.90 | GSK3B (0.76) | GSK3BPTAFRCDK2CLK1DYRK1A | |
| SCHEMBL5243802 | 0.88 | GSK3B (0.55) | GSK3BPTAFRNAMPT | |
| SCHEMBL5235357 | 0.82 | GSK3B (0.66) | GSK3BCDK2CLK1DYRK1ACLK4 | |
| SCHEMBL5231224 | 0.81 | GSK3B (0.46) | GSK3BPTAFRPARP1NAMPT | |
| SCHEMBL5231115 | 0.80 | GSK3B (0.46) | GSK3BPTAFRPARP1GSK3ANAMPT | |
| SCHEMBL5242783 | 0.78 | PTAFR (0.49) | GSK3BPTAFR | |
| SCHEMBL5237798 | 0.77 | AKT3 (0.44) | GSK3BAKT3CLK1DYRK1ACLK4 | |
| SCHEMBL13987027 | 0.76 | GSK3B (1.00) | GSK3BPTAFRCDK2CLK1DYRK1A | |
| SCHEMBL16892977 | 0.75 | AKT3 (0.46) | GSK3BPDK1AKT3CDK2CLK1 | |
| SCHEMBL13987029 | 0.74 | GSK3B (0.65) | GSK3BAKT3PARP1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611121-B1 | PYRIDAZINONE DERIVATIVES AS CDK2-INHIBITORS | AVENTIS PHARMA SA (FR) | 2007-08-08 | — | — | EP | claimed |