Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262638 | 0.90 | ALDH1A1 (0.41) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL6264209 | 0.84 | CDK5 (0.40) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL5227563 | 0.78 | MAPT (0.47) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL5262635 | 0.78 | MAPT (0.47) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL6264205 | 0.78 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL5231099 | 0.71 | MEN1 (0.44) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 | |
| SCHEMBL6252684 | 0.67 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10CYP2C9HPGD | |
| SCHEMBL5226363 | 0.66 | KDM4E (0.51) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL27580597 | 0.66 | ALDH1A1 (0.82) | ALDH1A1KDM4EHSD17B10CYP2C9HPGD | |
| SCHEMBL8006737 | 0.65 | ALDH1A1 (0.63) | ALDH1A1KDM4EHSD17B10CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581528-B1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | METRIS THERAPEUTICS LTD (GB) | 2007-08-01 | — | — | EP | disclosed |