Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262635 | 0.81 | MAPT (0.47) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL5227563 | 0.81 | MAPT (0.47) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL5262638 | 0.80 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL5231104 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5262632 | 0.74 | ALDH1A1 (0.38) | ALDH1A1MAPTL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL5231099 | 0.67 | MEN1 (0.44) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6264209 | 0.67 | CDK5 (0.40) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14432776 | 0.66 | TP53 (0.47) | ALDH1A1L3MBTL1CYP1A2LMNAPOLB | |
| SCHEMBL14432801 | 0.64 | CYP1A2 (0.41) | MAPTL3MBTL1CYP1A2LMNAKMT2A | |
| SCHEMBL5232381 | 0.63 | CCR5 (0.40) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581528-A1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | Metris Therapeutics Limited (GB) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058751-A1 | PIPERIDINYL-THIAZOLE CARBOXAMIDE DERIVATIVES FOR ALTERING VASCULAR TONE | METRIS THERAPEUTICS LIMITED (GB) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058750-A1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | METRIS THERAPEUTICS LIMITED (GB) | 2004-07-15 | — | — | WO | disclosed |