Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231104 | 0.84 | ALDH1A1 (0.45) | CDK5CDK5R1MEN1KMT2AALDH1A1 | |
| SCHEMBL5262638 | 0.81 | ALDH1A1 (0.41) | CDK5CDK5R1MEN1KMT2AALDH1A1 | |
| SCHEMBL5227563 | 0.72 | MAPT (0.47) | CDK5CDK5R1MEN1KMT2AALDH1A1 | |
| SCHEMBL5262635 | 0.72 | MAPT (0.47) | CDK5CDK5R1MEN1KMT2AALDH1A1 | |
| SCHEMBL6252684 | 0.70 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10HPGDCYP2C9 | |
| SCHEMBL5226363 | 0.69 | KDM4E (0.51) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6264205 | 0.67 | ALDH1A1 (0.40) | CDK5CDK5R1MEN1KMT2AALDH1A1 | |
| SCHEMBL27580597 | 0.62 | ALDH1A1 (0.82) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30936088 | 0.61 | ALDH1A1 (0.58) | CDK5CDK5R1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5231099 | 0.60 | MEN1 (0.44) | CDK5CDK5R1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581528-A1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | Metris Therapeutics Limited (GB) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058751-A1 | PIPERIDINYL-THIAZOLE CARBOXAMIDE DERIVATIVES FOR ALTERING VASCULAR TONE | METRIS THERAPEUTICS LIMITED (GB) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058750-A1 | PIPERIDINYL-THIAZOLE CARBOXYLIC ACID DERIVATIVES AS ANGIOGENESIS INHIBITORS | METRIS THERAPEUTICS LIMITED (GB) | 2004-07-15 | — | — | WO | disclosed |