Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 11/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235906 | 0.89 | HCRTR1 (0.46) | HCRTR1HCRTR2SLC22A12MEN1KMT2A | |
| SCHEMBL4692413 | 0.83 | HCRTR1 (0.53) | HCRTR1HCRTR2PLA2G10CCR5 | |
| SCHEMBL4692729 | 0.83 | HCRTR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL5231927 | 0.81 | CYP2C9 (0.42) | HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL5237741 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2PLA2G10CCR5 | |
| SCHEMBL5236364 | 0.80 | HCRTR1 (0.47) | HCRTR1HCRTR2PLA2G10CCR5 | |
| SCHEMBL4968486 | 0.80 | HCRTR1 (0.42) | HCRTR1HCRTR2CCR5 | |
| SCHEMBL5237460 | 0.79 | PLA2G10 (0.39) | MAPK1PLA2G10PLA2G2AHTR7 | |
| SCHEMBL5233682 | 0.79 | HCRTR1 (0.38) | HCRTR1HCRTR2SLC22A12MEN1KMT2A | |
| SCHEMBL5232788 | 0.79 | CHRNB2 (0.44) | MEN1LMNAMAPK1KMT2APLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |